ITT3829
ITT3829
- Catalog: ITT3829
- Gene/Protein: PPP2R5D
- Product Description: Immunotag™ PP2A-B56-δ Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | PP2A-B56-δ |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human PPP2R5D. AA range:544-593 |
Specificity | PP2A-B56-δ Polyclonal Antibody detects endogenous levels of PP2A-B56-δ protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | PPP2R5D |
Accession No. | Q14738 |
Alternate Names | PPP2R5D; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta |
Description | protein phosphatase 2 regulatory subunit B'delta(PPP2R5D) Homo sapiens The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | Oocyte meiosis,WNT,WNT-T CELL |
Protein Expression | Aorta endothelial cell,Bone marrow,Brain cortex,Col |
Subcellular Localization | protein phosphatase type 2A complex,nucleus,nucleoplasm,cytosol, |
Protein Function | function:The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.,induction:By retinoic acid; in neuroblastoma cell lines.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the phosphatase 2A regulatory subunit B56 family.,subcellular location:Nuclear in interphase, nuclear during mitosis.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1.,tissue specificity:Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |