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ITT4274

ITT4274
  • Catalog: ITT4274
  • Gene/Protein: SLC5A2
  • Product Description: Immunotag™ SGLT-2 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ SGLT-2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein SGLT-2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from SGLT-2, at AA range: 70-150
Specificity SGLT-2 Polyclonal Antibody detects endogenous levels of SGLT-2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name SLC5A2
Accession No. P31639 Q923I7 P53792
Alternate Names SLC5A2; SGLT2; Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
Description solute carrier family 5 member 2(SLC5A2) Homo sapiens This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015],
Protein Expression Kidney,
Subcellular Localization plasma membrane,integral component of plasma membrane,integral component of membrane,extracellular exosome,
Protein Function disease:Defects in SLC5A2 are the cause of renal glucosuria (GLYS1) [MIM:233100]. GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test.,function:Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.,function:Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.,similarity:Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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