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ITT4305

ITT4305
  • Catalog: ITT4305
  • Gene/Protein: SIX1
  • Product Description: Immunotag™ Six1 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ Six1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Six1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human SIX1. AA range:111-160
Specificity Six1 Polyclonal Antibody detects endogenous levels of Six1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name SIX1
Accession No. Q15475 Q62231
Alternate Names SIX1; Homeobox protein SIX1; Sine oculis homeobox homolog 1
Description SIX homeobox 1(SIX1) Homo sapiens The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008],
Protein Expression Muscle,
Subcellular Localization nucleus,transcription factor complex,nucleolus,cytoplasm,
Protein Function disease:Defects in SIX1 are the cause of autosomal dominant deafness type 23 (DFNA23) [MIM:605192].,disease:Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3) [MIM:608389]. Urinary tract malformations constitute the most frequent cause of chronic renal failure in the first two decades of life. Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder of kidney and urinary tract malformations with hearing loss. The major feature of BOR is hearing loss (93% of patients), which can be conductive, sensorineural, or both and varies in age of onset.,function:May be involved in limb tendon and ligament development.,similarity:Belongs to the SIX/Sine oculis homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Specifically expressed in skeletal muscle.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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