ITT4418
ITT4418
- Catalog: ITT4418
- Gene/Protein: SRSF5
- Product Description: Immunotag™ SRp40 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | SRp40 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,IF,ELISA |
Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from SRp40, at AA range: 40-120 |
Specificity | SRp40 Polyclonal Antibody detects endogenous levels of SRp40 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | SRSF5 |
Accession No. | Q13243 O35326 Q09167 |
Alternate Names | SRSF5; HRS; SFRS5; SRP40; Serine/arginine-rich splicing factor 5; Delayed-early protein HRS; Pre-mRNA-splicing factor SRP40; Splicing factor; arginine/serine-rich 5 |
Description | serine and arginine rich splicing factor 5(SRSF5) Homo sapiens The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], |
Cell Pathway/ Category | Spliceosome, |
Protein Expression | Brain,Colon,Epithelium,Fetal brain,Human endometrium carcin |
Subcellular Localization | nucleus,nucleoplasm,nucleolus,cytoplasm,nuclear speck, |
Protein Function | function:Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |