ITT4752
ITT4752
- Catalog: ITT4752
- Gene/Protein: TXNRD2
- Product Description: Immunotag™ TrxR2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | TrxR2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from TrxR2, at AA range: 440-520 |
| Specificity | TrxR2 Polyclonal Antibody detects endogenous levels of TrxR2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TXNRD2 |
| Accession No. | Q9NNW7 Q9JLT4 Q9Z0J5 |
| Alternate Names | TXNRD2; KIAA1652; TRXR2; Thioredoxin reductase 2; mitochondrial; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3 |
| Description | thioredoxin reductase 2(TXNRD2) Homo sapiens This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013], |
| Cell Pathway/ Category | Pyrimidine metabolism, |
| Protein Expression | Adrenal gland,Bone marrow,Brain,Cervix carcinoma,Fetal heart,Placenta,Pooled,Skin,T |
| Subcellular Localization | cell,mitochondrion,mitochondrial matrix, |
| Protein Function | catalytic activity:Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.,cofactor:FAD.,function:Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.,miscellaneous:The active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity.,sequence caution:Translated as Sec.,similarity:Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.,subunit:Homodimer.,tissue specificity:Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614 levels are low., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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