ITT4771
ITT4771
- Catalog: ITT4771
- Gene/Protein: TTF1
- Product Description: Immunotag™ TTF-I Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TTF-I |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TTF1. AA range:10-59 |
| Specificity | TTF-I Polyclonal Antibody detects endogenous levels of TTF-I protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TTF1 |
| Accession No. | Q15361 Q62187 |
| Alternate Names | TTF1; Transcription termination factor 1; TTF-1; RNA polymerase I termination factor; Transcription termination factor I; TTF-I |
| Description | transcription termination factor 1(TTF1) Homo sapiens This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011], |
| Protein Expression | Epithelium,Uterus, |
| Subcellular Localization | nucleus,nucleoplasm,nucleolus,cytoplasm,plasma membrane, |
| Protein Function | domain:The N-terminal region inhibits DNA-binding via its interaction with the C-terminal region.,function:Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with TIP5 recovers DNA-binding activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Contaminating sequence. Sequence of unknown origin in the C-terminal part.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 2 Myb-like domains.,subunit:Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments. Interacts with TIP5., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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