ITT4816
ITT4816
- Catalog: ITT4816
- Gene/Protein: UGDH
- Product Description: Immunotag™ UDP-GlcDH Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | UDP-GlcDH |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from UDP-GlcDH, at AA range: 360-440 |
| Specificity | UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | UGDH |
| Accession No. | O60701 O70475 O70199 |
| Alternate Names | UGDH; UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH |
| Description | UDP-glucose 6-dehydrogenase(UGDH) Homo sapiens The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
| Cell Pathway/ Category | Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Starch and sucrose metabolism,Amino sugar and nucleotide sugar metabolism, |
| Protein Expression | Liver,Placenta,Skin,Thymus, |
| Subcellular Localization | nucleus,nucleoplasm,cytosol,extracellular exosome, |
| Protein Function | catalytic activity:UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.,function:Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.,pathway:Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.,similarity:Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.,subunit:Homohexamer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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