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ITT4823

ITT4823
  • Gene/Protein: PLAU
  • Product Description: Immunotag™ uPA Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ uPA Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein uPA
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human uPA. AA range:190-239
Specificity uPA Polyclonal Antibody detects endogenous levels of uPA protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PLAU
Accession No. P00749 P06869
Alternate Names PLAU; Urokinase-type plasminogen activator; U-plasminogen activator; uPA
Description plasminogen activator, urokinase(PLAU) Homo sapiens This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
Cell Pathway/ Category Complement and coagulation cascades,
Protein Expression Brain,Lung,
Subcellular Localization extracellular region,extracellular space,plasma membrane,focal adhesion,cell surface,extracellular exosome,
Protein Function catalytic activity:Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.,function:Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.,online information:Urokinase entry,pharmaceutical:Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiates fibrinolysis. Clinically used for therapy of thrombolytic disorders.,PTM:Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 peptidase S1 domain.,subunit:Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.,tissue specificity:Expressed in the prostate gland and prostate cancers.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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