ITT5033
ITT5033
- Catalog: ITT5033
- Gene/Protein: FTO
- Product Description: Immunotag™ FTO Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | FTO |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the N-terminal region of human FTO |
| Specificity | FTO Polyclonal Antibody detects endogenous levels of FTO protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | FTO |
| Accession No. | Q9C0B1 Q8BGW1 Q2A121 |
| Alternate Names | FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein |
| Description | FTO, alpha-ketoglutarate dependent dioxygenase(FTO) Homo sapiens This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011], |
| Protein Expression | Brain,Cervix,Eye,Lung, |
| Subcellular Localization | nucleus,integral component of membrane,nuclear speck, |
| Protein Function | function:The precise function of this protein remains to be determined.,polymorphism:At least one intronic variation within the gene predisposes to childhood and adult obesity.,similarity:Belongs to the fto family.,tissue specificity:Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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