ITT5081
ITT5081
- Catalog: ITT5081
- Gene/Protein: UBE2A/UBE2B
- Product Description: Immunotag™ UBE2A/B Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | UBE2A/B |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from the C-terminal region of human UBE2A/B |
Specificity | UBE2A/B Polyclonal Antibody detects endogenous levels of UBE2A/B protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | UBE2A/UBE2B |
Accession No. | P49459/P63146 P63149 |
Alternate Names | UBE2A; RAD6A; Ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A; UBE2B; RAD6B; Ubiquitin-conjugating enzyme E2 B;RAD6 homolog B; HR6B; hHR6B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B |
Description | ubiquitin conjugating enzyme E2 A(UBE2A) Homo sapiens The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013], |
Cell Pathway/ Category | Ubiquitin mediated proteolysis, |
Protein Expression | Lung,Skin,Subthalamic nucleus,Thyroid, |
Subcellular Localization | chromatin,nuclear chromatin,XY body,cytoplasm,cytosol,HULC complex, |
Protein Function | catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with RAD18., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |