ITT5115
ITT5115
- Catalog: ITT5115
- Gene/Protein: JAM2
- Product Description: Immunotag™ JAM-B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | JAM-B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human JAM-B. |
| Specificity | JAM-B Polyclonal Antibody detects endogenous levels of JAM-B protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | JAM2 |
| Accession No. | P57087 Q9JI59 |
| Alternate Names | JAM2; C21orf43; VEJAM; Junctional adhesion molecule B; JAM-B; Junctional adhesion molecule 2; JAM-2; Vascular endothelial junction-associated molecule; VE-JAM; CD322 |
| Description | junctional adhesion molecule 2(JAM2) Homo sapiens This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration,Epithelial cell signaling in Helicobacter pylori infection, |
| Protein Expression | Lung,Placenta,Plasma,Vascular endothelial cell, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,bicellular tight junction,integral component of membrane, |
| Protein Function | function:May play a role in the processes of lymphocyte homing to secondary lymphoid organs.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subcellular location:Localized at tight junctions of both epithelial and endothelial cells.,subunit:Interacts with JAM3.,tissue specificity:Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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