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ITT5143

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ITT5143
  • Catalog: ITT5143
  • Gene/Protein: NR1H3
  • Product Description: Immunotag™ LXRα Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ LXRα Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein LXRα
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from LXRα, at AA range: 141-190
Specificity LXRα Polyclonal Antibody detects endogenous levels of LXRα protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name NR1H3
Accession No. Q13133 Q9Z0Y9 Q62685
Alternate Names NR1H3; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3
Description nuclear receptor subfamily 1 group H member 3(NR1H3) Homo sapiens The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Cell Pathway/ Category PPAR,
Protein Expression Brain,Liver,Placenta,
Subcellular Localization nuclear chromatin,nucleus,nucleoplasm,receptor complex,RNA polymerase II transcription factor complex,
Protein Function function:Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis.,induction:By 9-cis retinoic acid (9CRA).,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer of LXRA and RXR.,tissue specificity:Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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