ITT5157
ITT5157
- Catalog: ITT5157
- Gene/Protein: ALDH1A1
- Product Description: Immunotag™ ALDH1A1 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | ALDH1A1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALDH1A1. AA range:21-70 |
Specificity | ALDH1A1 Polyclonal Antibody detects endogenous levels of ALDH1A1 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | ALDH1A1 |
Accession No. | P00352 P24549 |
Alternate Names | ALDH1A1; ALDC; ALDH1; PUMB1; Retinal dehydrogenase 1; RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic |
Description | aldehyde dehydrogenase 1 family member A1(ALDH1A1) Homo sapiens The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011], |
Cell Pathway/ Category | Retinol metabolism, |
Protein Expression | Brain,Colon,Erythrocyte,Lens,Liver, |
Subcellular Localization | cytoplasm,cytosol,extracellular exosome, |
Protein Function | catalytic activity:Retinal + NAD(+) + H(2)O = retinoate + NADH.,function:Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |