ITT5288
ITT5288
- Catalog: ITT5288
- Gene/Protein: KLRC1/KLRC2/KLRC3
- Product Description: Immunotag™ CD159a/c Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD159a/c |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human KLRC1/2/3. AA range:101-150 |
| Specificity | CD159a/c Polyclonal Antibody detects endogenous levels of CD159a/c protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KLRC1/KLRC2/KLRC3 |
| Accession No. | P26715 |
| Alternate Names | KLRC1; NKG2A; NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a; KLRC2; NKG2C; NKG2-C type II integral membrane protein;CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor; CD159c; KLRC3; NKG2E; NKG2-E type II integral membrane protein; NK cell receptor E; NKG2-E-activating NK receptor |
| Description | killer cell lectin like receptor C1(KLRC1) Homo sapiens Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provide |
| Cell Pathway/ Category | Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Graft-versus-host disease, |
| Protein Expression | Blood,Kidney, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,integral component of membrane,receptor complex, |
| Protein Function | function:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.,online information:NKG-2A,similarity:Contains 1 C-type lectin domain.,subunit:Can form disulfide-bonded heterodimer with CD94.,tissue specificity:Natural killer cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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