ITT5490
ITT5490
- Catalog: ITT5490
- Gene/Protein: CRHR1
- Product Description: Immunotag™ CRF-RI Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CRF-RI |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Corticotropin-releasing factor receptor 1 at AA range: 71-120 |
| Specificity | CRF-RI Polyclonal Antibody detects endogenous levels of CRF-RI protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CRHR1 |
| Accession No. | P34998 P35347 P35353 |
| Alternate Names | CRHR1; CRFR; CRFR1; CRHR; Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1 |
| Description | corticotropin releasing hormone receptor 1(CRHR1) Homo sapiens This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction,Long-term depression, |
| Protein Expression | Brain,Hippocampus,Pituitary, |
| Subcellular Localization | endosome,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,intrinsic component of plasma membrane, |
| Protein Function | function:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,PTM:C-terminal Ser or Thr residues may be phosphorylated.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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