ITT5520
ITT5520
- Catalog: ITT5520
- Gene/Protein: TRPC3
- Product Description: Immunotag™ TRPC3 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | TRPC3 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from TRPC3, at AA range: 411-460 |
Specificity | TRPC3 Polyclonal Antibody detects endogenous levels of TRPC3 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | TRPC3 |
Accession No. | Q13507 Q9QZC1 Q9JMI9 |
Alternate Names | TRPC3; TRP3; Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3 |
Description | transient receptor potential cation channel subfamily C member 3(TRPC3) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011], |
Protein Expression | Brain,Embryonic kidney,Fetal brain, |
Subcellular Localization | plasma membrane,integral component of plasma membrane,integral component of membrane, |
Protein Function | function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 5 ANK repeats.,subunit:Interacts with TRPC1. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |