ITT5666
ITT5666
- Catalog: ITT5666
- Gene/Protein: TOP3A
- Product Description: Immunotag™ Topo IIIα Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | Topo IIIα |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from Topo IIIα . at AA range: 350-430 |
Specificity | Topo IIIα Polyclonal Antibody detects endogenous levels of Topo IIIα protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | TOP3A |
Accession No. | Q13472 O70157 |
Alternate Names | TOP3A; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha |
Description | topoisomerase (DNA) III alpha(TOP3A) Homo sapiens This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016], |
Cell Pathway/ Category | Homologous recombination, |
Protein Expression | Testis, |
Subcellular Localization | nucleus,nucleoplasm,chromosome,cytosol,PML body, |
Protein Function | catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,function:Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.,similarity:Belongs to the prokaryotic type I/III topoisomerase family.,subunit:Directly interacts with BLM and RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.,tissue specificity:High expression is found in testis, heart, skeletal muscle and pancreas., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |