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ITT5666

ITT5666
ITT5666
ITT5666
  • Catalog: ITT5666
  • Gene/Protein: TOP3A
  • Product Description: Immunotag™ Topo IIIα Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ Topo IIIα Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Topo IIIα
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from Topo IIIα . at AA range: 350-430
Specificity Topo IIIα Polyclonal Antibody detects endogenous levels of Topo IIIα protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name TOP3A
Accession No. Q13472 O70157
Alternate Names TOP3A; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha
Description topoisomerase (DNA) III alpha(TOP3A) Homo sapiens This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
Cell Pathway/ Category Homologous recombination,
Protein Expression Testis,
Subcellular Localization nucleus,nucleoplasm,chromosome,cytosol,PML body,
Protein Function catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,function:Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.,similarity:Belongs to the prokaryotic type I/III topoisomerase family.,subunit:Directly interacts with BLM and RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.,tissue specificity:High expression is found in testis, heart, skeletal muscle and pancreas.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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