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ITT5687

ITT5687
ITT5687-2
ITT5687
ITT5687-2
ITT5687
  • Catalog: ITT5687
  • Gene/Protein: TNFRSF17
  • Product Description: Immunotag™ CD269 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CD269 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CD269
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from the Internal region of human CD269.
Specificity CD269 Polyclonal Antibody detects endogenous levels of CD269 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name TNFRSF17
Accession No. Q02223 O88472
Alternate Names TNFRSF17; BCM; BCMA; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269
Description TNF receptor superfamily member 17(TNFRSF17) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Cytokine-cytokine receptor interaction,Intestinal immune network for IgA production,
Protein Expression Lymph node,Peripheral blood leukocyte,Pooled,
Subcellular Localization plasma membrane,endomembrane system,integral component of membrane,
Protein Function disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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