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ITT5689

ITT5689
ITT5689
ITT5689
  • Catalog: ITT5689
  • Gene/Protein: KCNK3
  • Product Description: Immunotag™ TASK-1 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ TASK-1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein TASK-1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from the N-terminal region of human TASK-1
Specificity TASK-1 Polyclonal Antibody detects endogenous levels of TASK-1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name KCNK3
Accession No. O14649 O35111 O54912
Alternate Names KCNK3; TASK; TASK1; Potassium channel subfamily K member 3; Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1; Two pore K(+) channel KT3.1
Description potassium two pore domain channel subfamily K member 3(KCNK3) Homo sapiens This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008],
Protein Expression Heart,Kidney,
Subcellular Localization plasma membrane,integral component of plasma membrane,integral component of membrane,
Protein Function function:pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.,miscellaneous:Inhibited by external acidification. Activated by halothane and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,tissue specificity:Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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