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ITT5782

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ITT5782
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ITT5782
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ITT5782
  • Catalog: ITT5782
  • Gene/Protein: CYFIP2
  • Product Description: Immunotag™ CYFIP2 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CYFIP2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CYFIP2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000, ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
Specificity CYFIP2 Polyclonal Antibody detects endogenous levels of CYFIP2
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CYFIP2
Accession No. Q96F07 Q5SQX6
Alternate Names Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Description disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
Cell Pathway/ Category Regulates Actin and Cytoskeleton,
Protein Expression Amygdala,Blood,Brain,Hippocampus,Liver,Lymph,
Subcellular Localization nucleus,cytoplasm,cytosol,membrane,cell junction,neuron projection,synapse,perinuclear region of cytoplasm,extracellular exosome,
Protein Function disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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