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  • Gene/Protein: CREB3
  • Product Description: Immunotag™ CREB3 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

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Immunotag™ CREB3 Polyclonal Antibody
Antibody Specification
Target Protein CREB3
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000, ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from the Internal region of human CREB3. AA range:151-200
Specificity CREB3 Polyclonal Antibody detects endogenous levels of CREB3
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CREB3
Accession No. O43889 Q61817
Alternate Names Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucin zipper proitein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]
Description cAMP responsive element binding protein 3(CREB3) Homo sapiens This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009],
Cell Pathway/ Category Melanogenesis,Huntington's disease,Prostate cancer,
Protein Expression Brain,Cervix carcinoma,Fetal liver,Pancreas,Skin,
Subcellular Localization Golgi membrane,nucleus,cytoplasm,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,cytosol,membrane,integral component of membrane,nuclear body,integral component of endoplasmic reticulum membrane
Protein Function function:Transcription factors activated upon intramembrane proteolysis (RIP), binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Binds to and requires HCFC1 as a coactivator. Activity and expression are suppressed when the HCFC1-CREB3 complex binds with CREBZF. Participates in LKN-1/CCL15-induced chemotaxis signaling.,PTM:During activation, an approximative 40 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under activation the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Interacts with CCR1. Interacts with HCFC1; required to activate it. Binds with CREBZF only when in combination with HCFC1. Interacts with HCV core protein.,tissue specificity:Ubiquitous.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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