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ITT5841

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ITT5841
  • Gene/Protein: IL31
  • Product Description: Immunotag™ IL-31 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ IL-31 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein IL-31
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from the Internal region of human IL31. AA range:21-70
Specificity The antibody detects endogenous IL-31
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name IL31
Accession No. Q6EBC2 Q6EAL8
Alternate Names Interleukin-31 (IL-31)
Description interleukin 31(IL31) Homo sapiens IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008],
Protein Expression Peripheral blood,
Subcellular Localization extracellular region,extracellular space,
Protein Function function:Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.,induction:Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).,tissue specificity:Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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