ITT5888
ITT5888
- Catalog: ITT5888
- Gene/Protein: HAVCR1 KIM1 TIM1 TIMD1
- Product Description: Immunotag™ TIM-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TIM-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 40-100 |
| Specificity | The antibody detects endogenous TIM-1 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HAVCR1 KIM1 TIM1 TIMD1 |
| Accession No. | Q96D42 Q5QNS5 |
| Alternate Names | Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell membrane protein 1) (TIM-1) (TIM) |
| Description | hepatitis A virus cellular receptor 1(HAVCR1) Homo sapiens The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. [provided by RefSeq, Apr 2015], |
| Protein Expression | Kidney,Liver, |
| Subcellular Localization | integral component of membrane,motile cilium, |
| Protein Function | function:May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.,polymorphism:HHAV seropositivity protects against atopy in individuals with the variants Met-Thr-Thr-Val-Pro-157 ins and Met-Thr-Thr-Thr-Val-Pro-157 ins. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.,similarity:Belongs to the immunoglobulin superfamily. TIM family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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