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ITT5914

ITT5914
ITT5914-3
ITT5914-2
ITT5914-4
ITT5914
ITT5914-3
ITT5914-2
ITT5914-4
  • Gene/Protein: TFF1 BCEI PS2
  • Product Description: Immunotag™ pS2 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

    Available Options

ITT5914

Immunotag™ pS2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein pS2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution IHC-p 1:50-200, ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthetic peptide from human protein at AA range: 10-50
Specificity The antibody detects endogenous pS2
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name TFF1 BCEI PS2
Accession No. P04155 Q08423
Alternate Names Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)
Description trefoil factor 1(TFF1) Homo sapiens Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008],
Protein Expression Colon,Gastric carcinoma,Kidney,Mammary cancer,Stomach,
Subcellular Localization extracellular space,
Protein Function disease:Expressed in a number of carcinomas including breast (50%), pancreas (70-75%), stomach (50-55%), and large bowel (58%).,function:Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.,similarity:Contains 1 P-type (trefoil) domain.,subunit:Heterodimer with GKN2; disulfide linked.,tissue specificity:Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level).,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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