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ITT5919

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ITT5919
  • Gene/Protein: MLL ALL1 CXXC7 HRX HTRX KMT2A MLL1 TRX1
  • Product Description: Immunotag™ MLL Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ MLL Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein MLL
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution IHC-p 1:50-200, ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthetic peptide from human protein at AA range: 3850-3900
Specificity The antibody detects endogenous MLL
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name MLL ALL1 CXXC7 HRX HTRX KMT2A MLL1 TRX1
Accession No. Q03164 P55200
Alternate Names Histone-lysine N-methyltransferase MLL (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Lysine N-methyltransferase 2A) (KMT2A) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Description lysine methyltransferase 2A(KMT2A) Homo sapiens This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefS
Protein Expression Brain,
Subcellular Localization nucleus,nucleoplasm,cytoplasm,histone methyltransferase complex,MLL1 complex,
Protein Function catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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