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ITT5932

ITT5932
ITT5932
ITT5932
  • Catalog: ITT5932
  • Gene/Protein: CD151 TSPAN24
  • Product Description: Immunotag™ CD151 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CD151 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CD151
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution IHC-p 1:50-200, ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthetic peptide from human protein at AA range: 91-140
Specificity The antibody detects endogenous CD151
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CD151 TSPAN24
Accession No. P48509 O35566 Q9QZA6
Alternate Names CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)
Description CD151 molecule (Raph blood group)(CD151) Homo sapiens The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008],
Protein Expression Colon,Kidney,Platelet,Prostate,Renal proximal tubule,
Subcellular Localization basement membrane,cytosol,plasma membrane,integral component of plasma membrane,focal adhesion,membrane,integral component of membrane,
Protein Function disease:Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]. NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.,function:Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.,induction:By HTLV-1.,online information:Blood group antigen gene mutation database,polymorphism:CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.,similarity:Belongs to the tetraspanin (TM4SF) family.,subunit:Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.,tissue specificity:Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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