ITT5932
ITT5932
- Catalog: ITT5932
- Gene/Protein: CD151 TSPAN24
- Product Description: Immunotag™ CD151 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | CD151 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,ELISA |
Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthetic peptide from human protein at AA range: 91-140 |
Specificity | The antibody detects endogenous CD151 |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | CD151 TSPAN24 |
Accession No. | P48509 O35566 Q9QZA6 |
Alternate Names | CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151) |
Description | CD151 molecule (Raph blood group)(CD151) Homo sapiens The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008], |
Protein Expression | Colon,Kidney,Platelet,Prostate,Renal proximal tubule, |
Subcellular Localization | basement membrane,cytosol,plasma membrane,integral component of plasma membrane,focal adhesion,membrane,integral component of membrane, |
Protein Function | disease:Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]. NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.,function:Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.,induction:By HTLV-1.,online information:Blood group antigen gene mutation database,polymorphism:CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.,similarity:Belongs to the tetraspanin (TM4SF) family.,subunit:Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.,tissue specificity:Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |