ITT5939
ITT5939
- Catalog: ITT5939
- Gene/Protein: FZD9 FZD3
- Product Description: Immunotag™ Frizzled-9 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | Frizzled-9 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,ELISA |
Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthetic peptide from human protein at AA range: 1-50 |
Specificity | The antibody detects endogenous Frizzled-9 |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | FZD9 FZD3 |
Accession No. | O00144 Q9R216 |
Alternate Names | Frizzled-9 (Fz-9) (hFz9) (FzE6) (CD antigen CD349) |
Description | frizzled class receptor 9(FZD9) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | WNT,WNT-T CELLMelanogenesis,Pathways in cancer,Colorectal cancer,Basal cell carcinoma, |
Protein Expression | Brain,Fetal brain,Oesophageal carcinoma, |
Subcellular Localization | cytoplasm,endoplasmic reticulum membrane,Golgi apparatus,plasma membrane,cell surface,integral component of membrane,filopodium membrane,mitochondrial membrane,perinuclear region of cytoplasm, |
Protein Function | caution:Has been first described as FZD3 in litterature.,domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,tissue specificity:Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |