ITT5955
ITT5955
- Catalog: ITT5955
- Gene/Protein: CCL20 LARC MIP3A SCYA20
- Product Description: Immunotag™ MIP-3α Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MIP-3α |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 31-80 |
| Specificity | The antibody detects endogenous MIP-3α |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CCL20 LARC MIP3A SCYA20 |
| Accession No. | P78556 O89093 |
| Alternate Names | C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)] |
| Description | C-C motif chemokine ligand 20(CCL20) Homo sapiens This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Chemokine, |
| Protein Expression | Liver,Pancreas, |
| Subcellular Localization | extracellular region,extracellular space,intracellular, |
| Protein Function | function:Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.,induction:By lipopolysaccharide (LPS), tumor necrosis factor and interferon gamma. Induced by phorbol myristate acetate (PMA) in U937 cell line and bowes melanoma. Repressed by IL-10.,online information:CCL20 entry,PTM:C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Binds to and activate CCR6.,tissue specificity:Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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