ITT6020
ITT6020
- Catalog: ITT6020
- Gene/Protein: GRB7
- Product Description: Immunotag™ GRB7 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | GRB7 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,ELISA |
Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthetic peptide from human protein at AA range: 30-100 |
Specificity | The antibody detects endogenous GRB7 |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | GRB7 |
Accession No. | Q14451 Q03160 |
Alternate Names | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) |
Description | growth factor receptor bound protein 7(GRB7) Homo sapiens The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011], |
Protein Expression | Liver,Lung,Oesophageal carcinoma,Thalamus, |
Subcellular Localization | cytosol,plasma membrane,focal adhesion,cytoplasmic stress granule,cell projection, |
Protein Function | At least 2 isoforms are produced,function:Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RND1., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |