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ITT6020

ITT6020
ITT6020
ITT6020
  • Catalog: ITT6020
  • Gene/Protein: GRB7
  • Product Description: Immunotag™ GRB7 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ GRB7 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein GRB7
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution IHC-p 1:50-200, ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthetic peptide from human protein at AA range: 30-100
Specificity The antibody detects endogenous GRB7
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name GRB7
Accession No. Q14451 Q03160
Alternate Names Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Description growth factor receptor bound protein 7(GRB7) Homo sapiens The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],
Protein Expression Liver,Lung,Oesophageal carcinoma,Thalamus,
Subcellular Localization cytosol,plasma membrane,focal adhesion,cytoplasmic stress granule,cell projection,
Protein Function At least 2 isoforms are produced,function:Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RND1.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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