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ITT6032

ITT6032-3
ITT6032
ITT6032-2
ITT6032-3
ITT6032
ITT6032-2
ITT6032
  • Catalog: ITT6032
  • Gene/Protein: CD247 CD3Z T3Z TCRZ
  • Product Description: Immunotag™ CD3 ζ Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CD3 ζ Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CD3 ζ
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution IHC-p 1:50-200, ELISA 1:10000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthetic peptide from human protein at AA range: 51-100
Specificity The antibody detects endogenous CD3 ζ
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CD247 CD3Z T3Z TCRZ
Accession No. P20963 P24161
Alternate Names T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)
Description CD247 molecule(CD247) Homo sapiens The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Natural killer cell mediated cytotoxicity,T_Cell_Receptor,
Protein Expression Pancreas,Skeletal muscle,T-cell,Thymus,
Subcellular Localization cytoplasm,plasma membrane,membrane,integral component of membrane,T cell receptor complex,alpha-beta T cell receptor complex,
Protein Function disease:Defects in CD247 are a cause of primary T-cell immunodeficiency [MIM:610163]. Affected individuals suffer of recurrent infections. Patients T-cell counts are very low and B-cell counts are normal.,domain:The ITAM domains mediate interaction with SHB.,function:Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.,online information:CD247 mutation db,PTM:Phosphorylated on Tyr residues after T-cell receptor triggering.,similarity:Belongs to the CD3Z/FCER1G family.,similarity:Contains 3 ITAM domains.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1 Nef protein. Interacts with SHB.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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