Datasheet |
|
Target Protein |
CD274 |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
IHC-p,ELISA |
Recommended Dilution |
IHC-p 1:50-200, ELISA 1:10000-20000 |
Concentration |
1 mg/ml |
Reactive Species |
Human |
Host Species |
Rabbit |
Immunogen |
Synthetic peptide from human protein at AA range: 181-230 |
Specificity |
The antibody detects endogenous CD274 |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name |
CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1 |
Accession No. |
Q9NZQ7 Q9EP73 |
Alternate Names |
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274) |
Description |
CD274 molecule(CD274) Homo sapiens This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], |
Cell Pathway/ Category |
Cell adhesion molecules (CAMs), |
Protein Expression |
Gastric carcinoma,Liver,Lung,Placenta, |
Subcellular Localization |
plasma membrane,external side of plasma membrane,endomembrane system,integral component of membrane,extracellular exosome, |
Protein Function |
function:Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.,induction:Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PDCD1.,tissue specificity:Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |