ITT6070
ITT6070
- Catalog: ITT6070
- Gene/Protein: GRIN1 NMDAR1
- Product Description: Immunotag™ GRIN1 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | GRIN1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from human GRIN1. at AA range: 840-880 |
Specificity | This antibody detects endogenous levels of GRIN1 |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | GRIN1 NMDAR1 |
Accession No. | Q05586 P35438 |
Alternate Names | Glutamate [NMDA] receptor subunit zeta-1 (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) |
Description | glutamate ionotropic receptor NMDA type subunit 1(GRIN1) Homo sapiens The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction,Long-term potentiation,Alzheimer's disease,Amyotrophic lateral sclerosis (ALS),Huntington's disease, |
Protein Expression | Brain,Cerebellum,Hippocampus, |
Subcellular Localization | endoplasmic reticulum,plasma membrane,integral component of plasma membrane,synaptic vesicle,cell surface,postsynaptic density,integral component of membrane,NMDA selective glutamate receptor complex,cell junction,dend |
Protein Function | function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.,online information:NMDA receptor entry,PTM:NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subcellular location:Enriched in post-synaptic plasma membrane and post-synaptic densities.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |