ITT6096
ITT6096
- Catalog: ITT6096
- Gene/Protein: C8A
- Product Description: Immunotag™ C8 α Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | C8 α |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human C8 α. at AA range: 201-250 |
| Specificity | C8 α Polyclonal Antibody detects endogenous levels of C8 α |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | C8A |
| Accession No. | P07357 Q8K182 |
| Alternate Names | Complement component C8 alpha chain (Complement component 8 subunit alpha) |
| Description | complement C8 alpha chain(C8A) Homo sapiens C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008], |
| Cell Pathway/ Category | Complement and coagulation cascades,Prion diseases,Systemic lupus erythematosus, |
| Protein Expression | Blood,Liver,Plasma, |
| Subcellular Localization | extracellular region,membrane attack complex,extracellular space,membrane,extracellular exosome,blood microparticle, |
| Protein Function | disease:Defects in C8A are a cause of complement C8 deficiency type I [MIM:120950]. Patients with deficiency of C8 suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C8 is a constituent of the membrane attack complex. C8 binds to the C5b-7 complex, forming the C5b-8 complex. C5-b8 binds C9 and acts as a catalyst in the polymerization of C9.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 TSP type-1 domains.,subunit:C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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