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Sodium meta-Periodate

Catalog Description Size Price(USD) Qty
BKC-12
Sodium metaperiodate 25g
$64.00
BKC-15
Sodium metaperiodate 5g
$24.00

Sodium meta-Periodate

Sodium metaperiodate, or sodium m-periodate, is a mild oxidant that is routinely used for the conversion of cis-glycol groups in carbohydrates to reactive aldehdye groups (Figure 1).  The reactive aldehyde groups are used in chemical conjugation procedures or detection of carbohydrates.  For proteomic research, sodium m-periodate is used for the oxidation of the carbohydrate moiety of glycoproteins and offers the advantage of modifying the sugar side chains as opposed to critical amino acids.

 
The resulting aldehydes can interact with primary amines to from Schiff’s bases, which in turn can be stabilized by reduction with sodium cyanoborohydride to form covalent amide bonds. Alternatively, the aldehydes can spontaneously react with hydrazide activated molecules to form relatively stable hydrazone bonds, which again can be stabilized with sodium cyanoborohydride.
 
Kit related to sodium metaperiodate is also available [Oxidative Modification Kit]
 

Features
  • A mild oxidizing agent that converts carbohydrates to activated active aldehydes
  • Used in coupling to amines with cyanborohydride reduction
    • Synonyms: Sodium m-periodate, sodium periodate
    • Linear formula:NaIO4
    • CAS #. 7790-28-5
    • Molecular weight: 213.89
    • Form: White  crystalline powder

 

Applications

  • Oxidation of glycoproteins for coupling chemistry or detection
  • For the generation of active aldehydes for reaction with primary amines to form Schiff's base
  • For the generation of active aldehydes to react with hydrazide activated molecules, such as HOOK Biotin-Hydrazide

 

 

Protocol
BKC-12
BKC-15
Material Safety Data Sheet
BKC-12
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BKC-15
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish
Technical Literature
Protein Labeling & Conjugation
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