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Recombinant Human ACE2

Recombinant Human ACE2
  • Gene/Protein: <a href=
  • Product Description: ACE-2
ACE-2
Protein Specification
Description

Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a 6His tag at the C-terminus.

Alternate Names

Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2

Accession No.

Q9BYF1

Amino Acid Range

Gln18-Ser740

Tag

C-6His

Species

Human

Source

Human cells

Background

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Product Form

Liquid

Formulation

Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 0.1mM ZnCl2, 10% Glycerol, pH 7.5.

Entotoxin Levels

Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.

Storage

Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/ice packs.

Datasheet

Material Safety Data Sheet
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