G-Biocide-II is thimerosal-based preservative. Thimerosal is an organomercury compound and derivative of thiosalicyclic acid. It has antibacterial and antifugal properties. Although its mechanism is not fully unraveled, it is known to inhibit sulfhydryl containing active site of various enzymes and binds sulfhydryl compounds such as glutathione, cysteine and SH groups of proteins. Furthermore, thimerosal activates the InsP3 calcium channel on endoplasmic reticular membrane and triggers release of calcium from intracellular stores. Thus thimeosal may induce or inhibit cellular functions depending on calcium signaling.
Form: 10 % thimerosal solution in water, sterile filtered.
Recommended concentration for use: as preservative upto 0.01% thimerosal concentration.
Used as preservative to preserve wide range of research reagents such as buffers, blocking solutions for ELISA, chromatography resins and Immunoglobulins storage solutions.