menu
Your Cart

PAX-8 Antibody IHC

Catalog Description Size Price(USD) Qty
786-1478
IHC Ab: PAX-8 0.1ml
$173.00
786-1479
IHC Ab: PAX-8 1ml
$757.00
786-1480
IHC Ab: PAX-8 5ml
$3,296.00

PAX-8 Antibody IHC

This antibody is intended for in vitro diagnostic (IVD) use.
 
The PAX-8 (IHC008) antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. Use of this antibody is indicated, subsequent to clinical differential diagnoses of diseases, as an aid in the identification of renal cell carcinoma, thyroid carcinoma, and ovarian carcinoma within the context of antibody panels, the patient’s clinical history and other diagnostic tests evaluated by a qualified pathologist.
 
PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.
Protocol
786-1478
786-1479
786-1480
Material Safety Data Sheet
786-1478
English_US
Danish
Dutch
English_UK
French
German
Norwegian
Portuguese
Swedish
Polish
786-1479
English_US
Danish
Dutch
English_UK
French
German
Norwegian
Portuguese
Swedish
Polish
786-1480
English_US
Danish
Dutch
English_UK
French
German
Norwegian
Portuguese
Swedish
Polish
Write a review
Note: HTML is not translated!
Bad Good
Captcha

Latest Blog

Download our handbooks

Custom Services

Connect With Us

Stay up to date with G-Biosciences by signing up for our newsletter.