G-Biosciences Bolton-Hunter Reagent conjugates tyrosine-like groups to end-terminal α-amino groups or ε-amino groups of lysine to increase the number of tyrosyl groups that can be iodinated by iodine-125 labeling procedures.
Radioactive iodine (125I) is routinely used by researchers to label proteins. The iodination of proteins can be performed enzymatically or chemically. The Bolton-Hunter reagent is designed to aid the labeling of proteins with radioactive iodine.
Click here for a water soluble Bolton-Hunter reagent.
- Optimal reaction at pH 8.5
- Ideal for proteins with masked or no tyrosine residues