Neomycin is a bactericidal aminoglycoside antibiotic. It binds to the 30S ribosome of susceptible organisms and interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.
Immobilized Neomycin is prepared by covalently coupling neomycin to an activated 6% cross-linked agarose and is used in isolation of neomycin binding proteins, receptors and specific antibodies.
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Neomycin coupled to 6% cross-linked Agarose
Coupling is covalent through linkage of amino or carboxyl group depending upon the antibiotic to the pre-activated agarose.
Available in 5 ml and 10 ml sizes
- Immobilized Neomycin is used for purification of neomycin binding proteins or receptors or specific antibodies.