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MT1 (Melatonin receptor 1)

Catalog Description Size Price(USD) Qty
786-1410
MT1 (Melatonin receptor 1) 10 µg
$1,721.00
786-1411
MT1 (Melatonin receptor 1) 50 µg
$7,942.00

MT1 (Melatonin receptor 1)

G-Biosciences offers full length, highly purified membrane proteins (GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins) for research in antibody development, vaccine formulation and/or drug discovery.  
 
A unique native isolation process was used to purify these integral membrane proteins with the highest purity levels while keeping their structural and functional integrity (no refolding or mutagenesis). This process conserves the functional and structural integrities of the targets/antigens. This has a significantly beneficial impact on the quality of the protein and on the success of the proteomics and drug discovery applications.

MT1 (Melatonin receptor 1) is a class A GPCR that modulates neuronal firing, arterial vasoconstriction, cell proliferation in cancer cells, and reproductive and metabolic functions.
 
MT1 (Melatonin receptor 1) is a good therapeutic candidate for insomnia, circadian sleep disorders, depression, cardiovascular regulation, cancer and neurodegenerative diseases.
 
Features
  • No refolding
  • No mutagenesis/truncation/fusion
  • Striking stability improvement
  • High purity
  • Maintain functional and structural integrities
Protein information
  • Class: GPCR Class A
  • Affinity Tag: Strepx2/His (both N-terminal)
  • Origin: Human 
  • Thero. MW: 44.8 kDa
  • Accession#: P48039 (UniProt)
Protein production
  • Purity: >90%
  • Concentration: Up to 5mg/ml
  • Expression system: Sf9 insect cells (baculovirus)
  • Purification: Immobilized Metal Affinity Chromatography
  • Activity: Confirmed by radiobinding assay and activation of Gi.
  • Storage conditions: Store at -80°C
Protocol
786-1410
786-1411
Material Safety Data Sheet
786-1410
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786-1411
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish
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