ITP1062
ITP1062
ITP1062
from
$541.00
Price in reward points: 541
- Catalog: ITP1062
- Gene/Protein: TTK
- Product Description: Immunotag™ TTK (phospho Thr676) Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein TTK (Thr676) Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,ELISA Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen The antiserum was produced against synthesized peptide derived from human TTK around the phosphorylation site of Thr676. AA range:642-691 Specificity Phospho-TTK (T676) Polyclonal Antibody detects endogenous levels of TTK protein only when phosphorylated at T676. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name TTK Accession No. P33981 P35761 Alternate Names TTK; MPS1; MPS1L1; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT Description TTK protein kinase(TTK) Homo sapiens This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009], Cell Pathway/ Category Cell_Cycle_G1S,Cell_Cycle_G2M_DNA, Protein Expression Epithelium,Eye,Testis, Subcellular Localization kinetochore,cytoplasm,spindle,membrane, Protein Function catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Present in rapidly proliferating cell lines., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | TTK (Thr676) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TTK around the phosphorylation site of Thr676. AA range:642-691 |
| Specificity | Phospho-TTK (T676) Polyclonal Antibody detects endogenous levels of TTK protein only when phosphorylated at T676. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TTK |
| Accession No. | P33981 P35761 |
| Alternate Names | TTK; MPS1; MPS1L1; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT |
| Description | TTK protein kinase(TTK) Homo sapiens This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009], |
| Cell Pathway/ Category | Cell_Cycle_G1S,Cell_Cycle_G2M_DNA, |
| Protein Expression | Epithelium,Eye,Testis, |
| Subcellular Localization | kinetochore,cytoplasm,spindle,membrane, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Present in rapidly proliferating cell lines., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |