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Cross-Linking & Modification

Download the Crosslinkers Handbook & Selection Guide            Download the Protein Labeling & Conjugation Handbook

 

 Cross-linking agents contain at least two reactive groups that are reactive towards numerous groups, including sulfhydryls, amines and carbohydrates, and create chemical covalent bonds between two or more molecules.  functional groups that can be targeted with cross-linking agents are primary amines, carboxyls, sulfhydryls,  carbohydrates and carboxylic acids. Protein molecules have many of these functional groups and therefore proteins and peptides can be readily conjugated using cross-linking agents. Cross-linking agents are used to study protein structure and function, to anchor proteins to solid  supports, preparation of immunogens, immunotoxins, and other conjugated protein reagents. G-Biosciences offers a variety of Double Do™ cross-linking agents, reaction specific buffers, and accessories for performing and facilitating crosslinking applications. These accessory tools simplify cross-linking reactions and will enable researchers to achieve highly efficient cross-linking reactions with minimal effort in reaction optimization, set-up, and procedure development

 
We offer a variety of amino acid side chain modifiers to block side chain interactions, change the charge or modify them to be more favorable for other reactions. Many denaturants, or chaotropes, are available and can disrupt water interactions resulting in the solubilization of hydrophobic proteins and peptides. Chaotropes act on proteins to unfold them and alter their three-dimensional structure. A wide selection of reagents and accessories are also available.
ρ-Azidobenzoyl Hydrazide Features Molecular Weight: 177.19 Spacer Arm (Å): 11.9 Reactive Toward: Carbohydrates Membrane Permeable: YES Water Soluble: NO Cleavable/ Reversible: NO                       ..
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N-5-Azido-2-nitrobenzyloxysuccinimide    Features Molecular Weight: 305.20 Spacer Arm (Å): 7.7 Reactive Toward: Primary Amines Membrane Permeable: YES Water Soluble: NO Cleavable/ Reversible: No..
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APDP A sulfhydryl-reactive and photoreactive cross-linker   Features Chemical Name: N-[4-(p-Azidosalicylamido)butyl]-3’-(2’-pyridyldithio)propionamide Synonym: APDP Formula: C₁₈H₂₀N₆O₂ Molecular Weight: 446.55 Spacer Arm: 21.0Å Reactive Toward: sulfhydryl and amino..
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ρ-Azidophenyl glyoxal monohydrate   Features Molecular Weight: 193.16 Spacer Arm (Å): 9.3 Reactive Toward: Arginines Membrane Permeable: YES Water Soluble: NO Cleavable/ Reversible: NO                     ..
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Bis(β-[4-azidosalicylamido]-ethyl) disulfide   Iodinatable     Features Molecular Weight: 474.52 Spacer Arm (Å): 21.3 Reactive Toward: Non Selective Membrane Permeable: YES Water Soluble: NO Cleavable/ Reversible: Reducing Agents (Thiols) &nb..
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G-Biosciences Bolton-Hunter Reagent conjugates  tyrosine-like groups to end-terminal α-amino groups or ε-amino groups of lysine to increase the number of tyrosyl groups that can be iodinated by iodine-125 labeling procedures.   Radioactive iodine (125I) is routinely us..
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(Bis(2-[Succinimidooxycarbonyloxy]ethyl) sulfone   Features Molecular Weight: 436.35 Spacer Arm (Å): 13 Reactive Toward: Primary Amines Membrane Permeable: YES Water Soluble: NO Cleavable/ Reversible: Base    ..
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1,4-Di-(3’-[2’pyridyldithio]-propionamido) butane   Features Molecular Weight: 428.71 Spacer Arm (Å): 19.9 Reactive Toward: Sulfhydryls Membrane Permeable: not done  Water Soluble: NO Cleavable/ Reversible: Reducing Agents (Thiols)    ..
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Dithiobis(succinimidyl propionate)   Features Molecular Weight: 404.42 Spacer Arm (Å): 12 Reactive Toward: Primary Amines Membrane Permeable: YES Water Soluble: NO Cleavable/ Reversible: Reducing Agents (Thiols)    ..
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Disuccinimidyl suberate   Ideal for receptor ligand cross-linking and coupling antibody to Protein A or G for immunoprecipitations.   OneQuant™ DSS is supplied as 8 vials of 2mg DSS, suitable for preparing for ~100µl 50mM stock solution from each vial.   Features ..
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Disuccinimidyl tartrate   Features Molecular Weight: 344.24 Spacer Arm (Å): 6.4 Reactive Toward: Primary Amines Membrane Permeable: YES Water Soluble: NO Cleavable/ Reversible: Oxidizing Agents (Periodate)    ..
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3,3’-Dithiobis(sulfosuccinimidyl propionate)   Features Molecular Weight: 608.51 Spacer Arm (Å): 12 Reactive Toward: Primary Amines Membrane Permeable: NO Water Soluble: YES Cleavable/ Reversible: Reducing Agents (Thiols)    ..
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