Amino Acid Side Chain Modifiers

A range of chemicals that modify amino acid side chains to block side chain interactions, change the charge or modify them to be more favorable for other reactions.

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Citraconic Anhydride

Citraconic anhydride reacts with primary amines and blocks them by creating an amide linkage and a terminal carboxylate (Figure 1).   The linkage is stable at neutral to alkaline pH (pH >7) ..

L-Cysteine•HCl monohdyrate

L-Cysteine hydrochloride salt is routinely used with Ellman's Reagent assays as a sulfhydryl standard. In addition, it is also used as a supplement for protein refolding experiments.Features CAS ..

p-Hydroxyphenylglyoxal (HPG)

HPG (p-hydroxyphenylglyoxal) reacts to specifically modify arginine residues under mild conditions to yield spectrophotometrically measurable signal for amino acid detection.   Features of HPG:..


Features Chemical Name: N-Succinimidyl S-acetylthioacetate CAS Number: 76931-93-6 Molecular Weight: 245.25 Reacts primarily with primary a..

Sulfo NHS Acetate

Features Chemical Name: Sulfosuccinimidyl acetate Reacts primarily with primary amines Reacts at pH 7-9 Water soluble Mol..


TNBS (2,4,6-trinitrobenzene sulfonic acid) is a highly sensitive and rapid chemical used to quantitate the free amino groups.  The reaction of TNBS with primary amines generates a highly chromoge..

Traut's Reagent

Features Chemical Name: 2-Iminothiolane hydrochloride Molecular weight: 137.63 Mild conditions: pH 7-10, 25°C Soluble in water ..


4-Vinylpyridine is used as a derivatizing reagent for free thiols such as GSH. It is used in the Glutathione colorimetric assay to remove reduced GSH, so that the oxidized Glutathione (GSSG) concentra..

Sodium meta-Periodate

Sodium metaperiodate, or sodium m-periodate, is a mild oxidant that is routinely used for the conversion of cis-glycol groups in carbohydrates to reactive aldehdye groups (Figure 1).  The reactiv..

Sulfo NHS

  Features       Chemical Name: N-Hydroxysulfosuccinimide Reacts primarily with primary amines Water soluble Molecular weight: 217.13..