| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1115-100MG | Thalidomide | 100mg | $105.00 | |
| GBM-1115-500MG | Thalidomide | 500mg | $420.00 |
| Bioassays Specification | |
| Bio-Activity | E3 Ubiquitin ligase inhibitor |
| Chemical Name | N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemic |
| Function / Pharmacology | Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic. |
| CAS# | 50-35-1 |
| MW | 258.25 |
| Molecular Formula | C13H10N2O4 |
| Solubility | Soluble in DMSO (up to 5 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345 / 2) Weglicki et al. (1993), Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency; Mol. Cell. Biochem., 129 195 / 3) D’Amato et al. (1994), Thalidomide is an inhibitor of angiogenesis ; Proc. Natl. Acad. Sci. USA, 91 4082 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | E3 Ubiquitin ligase inhibitor |
| Chemical Name | N-(2,6-Dioxo-3-piperidinyl)phthalimide, racemic |
| Function / Pharmacology | Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution, compound is teratogenic. |
| CAS# | 50-35-1 |
| MW | 258.25 |
| Molecular Formula | C13H10N2O4 |
| Solubility | Soluble in DMSO (up to 5 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345 / 2) Weglicki et al. (1993), Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency; Mol. Cell. Biochem., 129 195 / 3) D’Amato et al. (1994), Thalidomide is an inhibitor of angiogenesis ; Proc. Natl. Acad. Sci. USA, 91 4082 |
| Protein Specification | |
| Purity | >98% |
