P7C3
P7C3
P7C3
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1150-5MG | P7C3 | 5mg | $126.00 | |
| GBM-1150-25MG | P7C3 | 25mg | $504.00 |
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Description
NAMPT activator; Neuroprotective
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Specifications
Bioassays Specification Bio-Activity NAMPT activator; Neuroprotective Chemical Name 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol Function / Pharmacology P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis.2 Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease.3 Restores hippocampal neurogenesis in a mouse model of Down Syndrome.4 The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD.5 Active in vivo. CAS# 301353-96-8 MW 474.20 Molecular Formula C21H18Br2N2O Solubility Soluble in DMSO (up to 30 mg/ml). Supplied powder Storage as supplied -20°C Ship temp Ambient References 1) Pieper et al. (2010), Discovery of a proneurogenic, neuroprotective chemical; Cell, 142 39 2) Tesla et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis; Proc. Natl. Acad. Sci. USA, 109 17016 3) De Jesus-Cortes et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease; Proc. Natl. Acad. Sci. USA, 109 17010 4) Latchney et al. (2015), Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome; Neurosci. Lett. 591 86 5) Wang et al. (2014), P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage; Cell, 158 1324 Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | NAMPT activator; Neuroprotective |
| Chemical Name | 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol |
| Function / Pharmacology | P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis.2 Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease.3 Restores hippocampal neurogenesis in a mouse model of Down Syndrome.4 The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD.5 Active in vivo. |
| CAS# | 301353-96-8 |
| MW | 474.20 |
| Molecular Formula | C21H18Br2N2O |
| Solubility | Soluble in DMSO (up to 30 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Pieper et al. (2010), Discovery of a proneurogenic, neuroprotective chemical; Cell, 142 39 2) Tesla et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis; Proc. Natl. Acad. Sci. USA, 109 17016 3) De Jesus-Cortes et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease; Proc. Natl. Acad. Sci. USA, 109 17010 4) Latchney et al. (2015), Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome; Neurosci. Lett. 591 86 5) Wang et al. (2014), P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage; Cell, 158 1324 |
| Protein Specification | |
| Purity | >98% |