| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1158-50MG | 2-Chloroadenosine | 50mg | $168.00 | |
| GBM-1158-250MG | 2-Chloroadenosine | 250mg | $672.00 |
| Bioassays Specification | |
| Bio-Activity | A1 adenosine agonist |
| Chemical Name | 6-Amino-2-chloropurine riboside |
| Function / Pharmacology | A metabolically stable adenosine analog that acts as an agonist at A1, A2a, and A3 adenosine receptors (Ki = 300, 80, 1900 nM)1. 2-Chloroadenosine is also a bidirectional substrate for equilibrative nucleoside transporter 4 (ENT4) in acidic conditions2. At 100 µM, it causes accumulation of cAMP in neonatal mouse osteoblast-like cells3. Reduces intracellular ATP levels through both ATP consumption and AMP deamination, and induces apoptosis in leukemic B-cells and rheumatoid fibroblasts4,5. |
| CAS# | 146-77-0 |
| MW | 301.7 |
| Molecular Formula | C10H12ClN5O4 |
| Solubility | Soluble in DMSO (up to 30 mg/ml) or in Water (up to 7 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. RA Mathoôt et al. Br. J. Pharmacol. 1996 118:369 2. D Tandio et al. Sci. Rep. 2019 9:13555 3. UH Lerner et al. Acta Physiol. Scand. 1987 131:287 4. L Bastin-Coyette et al. Biochem. Pharmacol. 2008 75:1451 5. M Koshiba et al. Br. J. Pharmacol. 2002 135:1477 |
| Antibody Specification | |
| Alternate Names | 2-CAdo; 2-CADO; 2-Cl Ado |
| Protein Specification | |
| Purity | >95% |
| Bioassays Specification | |
| Bio-Activity | A1 adenosine agonist |
| Chemical Name | 6-Amino-2-chloropurine riboside |
| Function / Pharmacology | A metabolically stable adenosine analog that acts as an agonist at A1, A2a, and A3 adenosine receptors (Ki = 300, 80, 1900 nM)1. 2-Chloroadenosine is also a bidirectional substrate for equilibrative nucleoside transporter 4 (ENT4) in acidic conditions2. At 100 µM, it causes accumulation of cAMP in neonatal mouse osteoblast-like cells3. Reduces intracellular ATP levels through both ATP consumption and AMP deamination, and induces apoptosis in leukemic B-cells and rheumatoid fibroblasts4,5. |
| CAS# | 146-77-0 |
| MW | 301.7 |
| Molecular Formula | C10H12ClN5O4 |
| Solubility | Soluble in DMSO (up to 30 mg/ml) or in Water (up to 7 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. RA Mathoôt et al. Br. J. Pharmacol. 1996 118:369 2. D Tandio et al. Sci. Rep. 2019 9:13555 3. UH Lerner et al. Acta Physiol. Scand. 1987 131:287 4. L Bastin-Coyette et al. Biochem. Pharmacol. 2008 75:1451 5. M Koshiba et al. Br. J. Pharmacol. 2002 135:1477 |
| Antibody Specification | |
| Alternate Names | 2-CAdo; 2-CADO; 2-Cl Ado |
| Protein Specification | |
| Purity | >95% |
