| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1180-5MG | Pifithrin mu | 5mg | $95.00 | |
| GBM-1180-25MG | Pifithrin mu | 25mg | $357.00 |
| Bioassays Specification | |
| Bio-Activity | Hsp70 inhibitor |
| Chemical Name | 2-Phenylethynesulfonamide |
| Function / Pharmacology | Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Recues primary mouse thymocytes from P53-mediated apoptosis induced by radiation. Cell permeable. |
| CAS# | 64984-31-2 |
| MW | 181.21 |
| Molecular Formula | C8H7NO2S |
| Solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Leu et al. (2009), The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53.; Mol. Cell, 36 15. / 2) Strom et al. (2006), Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.; Nat. Chem. Biol., 2 474 |
| Antibody Specification | |
| Alternate Names | PES; NSC-303580 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Hsp70 inhibitor |
| Chemical Name | 2-Phenylethynesulfonamide |
| Function / Pharmacology | Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Recues primary mouse thymocytes from P53-mediated apoptosis induced by radiation. Cell permeable. |
| CAS# | 64984-31-2 |
| MW | 181.21 |
| Molecular Formula | C8H7NO2S |
| Solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Leu et al. (2009), The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53.; Mol. Cell, 36 15. / 2) Strom et al. (2006), Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.; Nat. Chem. Biol., 2 474 |
| Antibody Specification | |
| Alternate Names | PES; NSC-303580 |
| Protein Specification | |
| Purity | >98% |
