Entacapone
Entacapone
Entacapone
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2025-10MG | Entacapone | 10mg | $84.00 | |
| GBM-2025-50MG | Entacapone | 50mg | $231.00 |
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Description
COMT inhibitor; Anti-Parkinsons
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Specifications
Bioassays Specification Bio-Activity COMT inhibitor; Anti-Parkinsons Chemical Name (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Function / Pharmacology Potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of L-DOPA as adjunct therapy for Parkinson's disease.2 Inhibits α-synuclein aggregation in vitro and inhibits α-synuclein-induced cell death in PC-12 cells3. Antioxidant. Inhibits oxidative stress-induced cell death4. CAS# 130929-57-6 MW 305.29 Molecular Formula C14H15N3O5 Solubility Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml). Supplied powder Storage as supplied -20°C Ship temp Ambient References 1) Forsberg et al. (2003), Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat; J. Pharmacol. Exp. Ther., 304 498 2) Merello et al. (1994), Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson’s disease; J. Neurol. Neurosurg. Psychiatry, 57 186 3) Giovanni et al. (2010), Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta amyloid and protect against amyloid-induced toxicity; J. Biol. Chem., 285 14941 4) Chen et al. (2016), Entacapone is an Antioxident More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-induced Cell Death; Med. Sci. Monit., 22 687 Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | COMT inhibitor; Anti-Parkinsons |
| Chemical Name | (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide |
| Function / Pharmacology | Potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of L-DOPA as adjunct therapy for Parkinson's disease.2 Inhibits α-synuclein aggregation in vitro and inhibits α-synuclein-induced cell death in PC-12 cells3. Antioxidant. Inhibits oxidative stress-induced cell death4. |
| CAS# | 130929-57-6 |
| MW | 305.29 |
| Molecular Formula | C14H15N3O5 |
| Solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Forsberg et al. (2003), Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat; J. Pharmacol. Exp. Ther., 304 498 2) Merello et al. (1994), Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson’s disease; J. Neurol. Neurosurg. Psychiatry, 57 186 3) Giovanni et al. (2010), Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta amyloid and protect against amyloid-induced toxicity; J. Biol. Chem., 285 14941 4) Chen et al. (2016), Entacapone is an Antioxident More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-induced Cell Death; Med. Sci. Monit., 22 687 |
| Protein Specification | |
| Purity | >98% |