Losartan potassium
Losartan potassium
Losartan potassium
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2294-100MG | Losartan potassium | 100mg | $84.00 | |
| GBM-2294-500MG | Losartan potassium | 500mg | $336.00 |
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Description
Angiotensin AT1 receptor antagonist
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Specifications
Bioassays Specification Bio-Activity Angiotensin AT1 receptor antagonist Chemical Name 2-Butyl-4-chloro-1-{[2’-(1H-tetrazol-5-yl)(1,1’-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt Function / Pharmacology Non-peptide angiotensin II receptor antagonist.1,2 Clinically useful antihypertensive agent.3 Inhibits collagen I synthesis.4 Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model.5 Displays neuroprotective effects along with nimesulide against chronic fatigue stress.6 Displays myocardial antifibrotic activity.7 CAS# 124750-99-8 MW 461.01 Molecular Formula C22H22ClKN6O Solubility Soluble in DMSO (up to 20 mg/ml). Supplied powder Storage as supplied -20°C Ship temp Ambient References 1) Merck 14:5583 2) Chiu et al. (1990), Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent; J. Pharmacol. Exp. Ther., 252 711 3) McIntyre et al. (1997), Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of it’s efficacy and safety in essential hypertension; Pharmacol. Ther., 74 181 4) Diop-Frimpong et al. (2011), Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors; Proc. Natl. Acad. Sci. USA, 108 2909 5) Pantazi et al. (2015), Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation; World J. Gastroenterol., 21 8021 6) Kumar et al. (2015), Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress; Inflammopharmacology, 23 291 7) Miguel-Carrasco et al. (2017), Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites; Sci. Rep. 7 41865 Antibody Specification Alternate Names DUP-753 Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | Angiotensin AT1 receptor antagonist |
| Chemical Name | 2-Butyl-4-chloro-1-{[2’-(1H-tetrazol-5-yl)(1,1’-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt |
| Function / Pharmacology | Non-peptide angiotensin II receptor antagonist.1,2 Clinically useful antihypertensive agent.3 Inhibits collagen I synthesis.4 Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model.5 Displays neuroprotective effects along with nimesulide against chronic fatigue stress.6 Displays myocardial antifibrotic activity.7 |
| CAS# | 124750-99-8 |
| MW | 461.01 |
| Molecular Formula | C22H22ClKN6O |
| Solubility | Soluble in DMSO (up to 20 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Merck 14:5583 2) Chiu et al. (1990), Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent; J. Pharmacol. Exp. Ther., 252 711 3) McIntyre et al. (1997), Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of it’s efficacy and safety in essential hypertension; Pharmacol. Ther., 74 181 4) Diop-Frimpong et al. (2011), Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors; Proc. Natl. Acad. Sci. USA, 108 2909 5) Pantazi et al. (2015), Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation; World J. Gastroenterol., 21 8021 6) Kumar et al. (2015), Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress; Inflammopharmacology, 23 291 7) Miguel-Carrasco et al. (2017), Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites; Sci. Rep. 7 41865 |
| Antibody Specification | |
| Alternate Names | DUP-753 |
| Protein Specification | |
| Purity | >98% |