| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2428-10MG | TCID | 10mg | $168.00 | |
| GBM-2428-50MG | TCID | 50mg | $672.00 |
| Bioassays Specification | |
| Bio-Activity | DUB inhibitor |
| Chemical Name | 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione |
| Function / Pharmacology | Inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 µM, 125-fold selective over UCH-L1, IC50=75 µM. Cell permeable. |
| CAS# | 30675-13-9 |
| MW | 283.93 |
| Molecular Formula | C9H2Cl4O2 |
| Solubility | Soluble in DMSO (up to 25 mg/ml), |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697 / 2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | DUB inhibitor |
| Chemical Name | 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione |
| Function / Pharmacology | Inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 µM, 125-fold selective over UCH-L1, IC50=75 µM. Cell permeable. |
| CAS# | 30675-13-9 |
| MW | 283.93 |
| Molecular Formula | C9H2Cl4O2 |
| Solubility | Soluble in DMSO (up to 25 mg/ml), |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697 / 2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022 |
| Protein Specification | |
| Purity | >98% |
